Spatial isolation in the area of the city always has encouraged other social and economic isolation. So far, the approaches taken without regard to the "Behavior of citizens" of urban space, just based on the subjective perception of designers and architects, who could not open the knot of problems of the city. So it seems that the effects of the structure and spatial configuration of these tissues the pedestrian motion flow is an important factor in the analysis of spatial isolation. Hence this article in February 2016 with with the aim of analyzing the spatial isolation of Zanjan ranging from worn-out tissues and old and worn out tissues in the overall structure of the city, based on the behavior of the human factor, Space Syntax method was performed. The research was descriptive - analytical and theoretical data were collected through library research. Analyzes conducted two analyzes the layout of space that include: A) analysis of structural parameters spatial street network, the data and information through a central axial map analysis software to help Atocad, depth map and Arc GIS environments obtained in the form of tables, graphs and maps have been extracted. B) Analysis Agent, one of the collections in the application of space syntax analysis was performed depth map. In this analysis, spatial isolation was based on the simulation model of pedestrian behavior.

The results show that firstly; How to establish relationships and spatial arrangements in urban tissues spatial isolation is a major factor in the analysis of different species. Second, using the analysis Agent, based on the theory of natural movement, it was concluded that the old and new tissues Zanjan, the movement of pedestrians important role in the occurrence or non-occurrence of spatial isolation have.